Impression Cytology in Different Types of Contact Lens Users
Medical hypothesis discovery and innovation in ophthalmology,
Vol. 4 No. 3 (2015),
1 September 2015
Abstract
This study compared tear function tests and cytologic changes on the conjunctival surface in asymptomatic patients wearing contact lens of different materials. Included in this study were 40 eyes wearing daily wear 4 week replacement hydrogel (H) lenses, 32 eyes wearing silicone hydrogel (SiH) lenses, 18 eyes wearing rigid gas-permeable (RGP) lenses, and 21 healthy eyes (no lenses) as the control group. Epithelial morphology of the conjunctival surface was evaluated, based on Nelson classification with conjunctival impression cytology (CIC), after the tear break-up time (TBUT) and Schirmer test were performed. The mean values of the Schirmer and TBUT tests were significantly higher in the control group than in the other lens groups (p < 0.001). Grade 0 was the most frequent CIC in the control group (66.7%) and least frequent in the SiH lens group (40.6%); grade I was least frequent in the control and RGP groups (33.3%) and most frequent in the SiH lens group (40.6%). Moreover, grade 2 was most frequent in the SiH lens group (18.8%). There was no statistically significant difference in goblet cell densities between the groups (p = 0.462). In addition to the different Schirmer and TBUT test results between contact lens wearers and healthy non-wearers, some cytologic changes may occur on the ocular surface with direct mechanical effects of contact lenses. This simple and noninvasive technique may be used to evaluate the ocular surface with regard to intolerance to contact lenses.References
Tomatir DK, Erda N, Gürlü VP. Effects of different contact lens materials and contact lens-wearing periods on conjunctival cytology in asymptomatic contact lens wearers. Eye Contact Lens. 2008 May;34:166-168. PMID: 18463482
Egbert PR, Lauber S, Maurice DM. A simple conjunctival biopsy. Am J Ophthalmol. 1977;84:798-801. PMID: 596392
Simon P, Jaison SG, Chopra SK, Jacob S. Conjunctival impression cytology in contact lens wearers. Indian J Ophthalmol. 2002;50:301-306. PMID: 12532495
Aragona P, Ferreri G, Micali A, Puzzolo D. Morphological changes of the conjunctival epithelium in contact lens wearers evaluated by impression cytology. Eye. 1998;12:461-466. PMID: 9775250
Adar S, Kanpolat A, Sürücü S, Ucakhan OO. Conjunctival impression cytology in patients wearing contact lenses. Cornea. 1997;16:289-294. PMID: 9143800
Knop E, Brewitt H. Conjunctival cytology in asymptomatic wearers of soft contact lenses. Graefes Arch Clin Exp Ophthalmo.l 1992;230:340-347. PMID: 1505765
Nelson JD, Havener VR, Cameron JD. Cellulose acetate impressions of the ocular surface. Arch Ophthalmol. 1983;101:1869-1872. PMID: 6651590
Cakmak SS, Unlü MK, Karaca C, Nergiz Y, Ipek S. Effect of soft contact lenses on conjunctival surface. Eye&Contact Lens. 2003;29:230-233. PMID: 14555898
Lievens CW, Connor CG, Murphy H. Comparing goblet cell densities in patients wearing disposable hydrogel contact lenses versus silicone hydrogel contact lenses in an extended-wear modality. Eye&Contact Lens. 2003;29:241-244. PMID: 14555901
Rivas L, Oroza MA, Perez-Esteban A, Murube-del-Castillo J. Morphological changes in ocular surface in dry eyes and other disorders by impression cytology. Graefes Arch Clin Exp Ophthalmol. 1992;230:329–334. PMID: 1505763
Anshu, Munshi MM, Sathe V, Ganar A. Conjunctival impression cytology in contact lens wearers. Cytopathology. 2001;12:314-320. PMID: 11722511
Paschides CA, Petroutsos G, Psilas K. Correlation of conjunctival impression cytology results with lacrimal function and age. Acta Ophthalmol (Copenh). 1991;69:422-425. PMID: 1750308
Yeo AC, Carkeet A, Carney LG, Yap MK. Relationship between goblet cell density and tear function tests. Ophthalmic Physiol Opt. 2003;23:87-94. PMID: 12535061
- Abstract Viewed: 2099 times
- PDF Downloaded: 2005 times